Teamed with Doyen Medipharm, J-PAC Packages HemoSense Test Strips
Medipharm Manufacturing Group (MMG) is tracking changing trends in drug delivery.
J-PAC (Somersworth, NJ) and Doyen Medipharm (Lakeland, FL; and Norfolk,UK) have merged to form the Medipharm Manufacturing Group, combining Doyen Medipharm’s machinery manufacturing with J-PAC’s expertise in medical device manufacturing and contract packaging for sterile disposable medical devices.
MMG provides capabilities in material conversion and packaging aimed to address the “dramatic” changes in packaging of environmentally sensitive products, says Richard Crane, vice president, technical marketing and new business development, J-PAC. These include noninvasive delivery systems, chemically active product formats, and unit-of-use packaging for home-based care.
The two companies provide complementary strengths, Crane says. J-PAC offers expertise for helping companies develop products and packaging. “We can go after products such as in vitro diagnostics, implantables, and eluting films and polymers. Companies want to know how to make the product and automate production. J-PAC provides design, development, and manufacturing services for products in small-to-medium quantities initially. You need to design a product that is as robust as possible and that can be affordably produced in high volume. Then we can scale people up to the appropriate level of automation,” says Crane.
“Doyen Medipharm has great web-handling capabilities for converting materials that are challenging to process. Materials for products such as transdermal and transmucosal films and active wound dressings have difficult dimensional integrity and textures,” Crane says.
In-line production often involves the application of preformulated medicaments in dosed formats. The companies provide cleanroom and dryroom production resources that are needed when drugs are incorporated into devices and packaging. “Doyen’s transdermal and transmucosal equipment draws J-PAC into the pharmaceutical arena,” says Crane.
Unit-of-use packaging formats are supporting the trend to home-based care. “Where possible, healthcare treatment and diagnosis is transitioning to the home. As you move treatment from the clinical setting to the home, packaging has to change to unit-of-use forms that provide ready-to-use product to an inexperienced patient,” he says.
J-PAC recently began packaging test strips used in the HemoSense INRatio blood-monitoring system that provides a home-based diagnostics solution.
HemoSense Inc. (San Jose) opted for the contract packaging services this year to expand its INRatio test-strip production capacity. Patients taking the oral anticoagulant Warfarin use the HemoSense system for monitoring blood anticoagulation levels. HemoSense test strips employ reagent-based electrochemical technology. The blood drop is subjected to an electrical charge from test-strip electrodes that interface with the monitor.
Strips are packaged in a humidity-controlled environment in Somersworth, NH, on a Doyen Medipharm 4SS 100 four-side-seal machine. The package is a flexible five-layer polyethylene/foil construction with a tear-notch opening. A 0.5-g molecular sieve desiccant pack is added before sealing and cutting.
J-PAC will shortly launch production of its first OTC package, a unit-of-use pack produced on a Doyen Medipharm thermoformer, says Crane.
Doyen Medipharm previously expanded into contract packaging by producing the Zicam cold remedy swab at its Lakeland facilities. Doyen uses its thermoforming FFS unit with an Ivek dispensing system for adding the dose of medicament. The patented flexible high-barrier unit-of-use package design allows users to apply the nasal medication without touching the gel-coated swab.