Interphex 2012 will be held at New York City’s Jacob K. Javits Center on May 1-3, 2012. Headlining this event will be a series of keynote presentations presented by leading subject matter experts.
For instance, on Tuesday, May 1, at 9:15 am - 10:15 am, in “What the New Bio/Pharma Business Model Means for CMOs and CROs,” James C. Miller, President and CEO of PharmSource Information Services, Inc., will outline the transformation of today’s bio/pharma business model and the opportunities and challenges it presents to providers of development and manufacturing services.
On Tuesday, May 1, 1:30 pm - 2:30 pm, in “Control, Capability, and Capacity: Elements Assuring a Reliable Drug Supply,” Jeffrey C. Baker, Ph.D., Deputy Director, Office of Biotechnology Products, Center for Drug Evaluation & Research, FDA. He will provide a technical/historical context for discussions currently underway in which FDA is partnering with industry to better understand and control factors that can compromise the ability to deliver high quality medicines in a reliable way.
On Wednesday, May 2, 10:15 am - 11:15 am, in “Creating Innovative Cold Chain Solutions for your Pharmaceutical and Biopharmaceutical Products,” Richard Smith, Director, Life Sciences & Specialty Services, FedEx, will address the role of FedEx’s global air network, visibility, and intervention capabilities in cold chain supply. This includes a number of services and temperature-controlled capabilities to overcome challenges faced by the pharmaceutical and biopharmaceutical companies, in addition to cost-effective global room temperature solutions. Smith is the son of FedEx founder Frederick W. Smith.
There is also a full conference track, including “Why Supply Chain Security is so Important in Today’s Marketplace” on May 2 at 1:30 pm - 2:30 pm and “Applying a Knowledge-Based Approach to Supply Chain Pharmaceutical Temperature Control Management” on May 2 at 2:45 pm - 3:45 pm.
For more details on the conferences and the exhibition, visit www.INTERPHEX.com . Follow INTERPHEX on Facebook, LinkedIn and Twitter (@INTERPHEX).
A partnership between two companies will demonstrate a state-of-the-art microdosing system and a sensor that works to ensure accurate, repeatable powder microdoses. VisioAMV is a non-contact sensor used to verify mass. With pharmaceutical doses becoming more potent and smaller in volume, it has become more challenging to verify microgram product doses without line stoppage for sampling, or using elaborate and delicate mechanical systems for 100% checks. VisioTec’s VisioAMV uses non-contact capacitance technology to verify product mass passing through its sensor, making it ideal for sterile conditions in unidirectional air environments. Verifying the product dose at the dispensing area is the ideal situation for monitoring 100% of doses, the companies report. This “capacitive” technology observes a product’s influence in an electrical field by reading and registering a telltale signal correlating to the mass of each product passing through. Potential processes for VisioAMV applications include powder filling, capsule filling (powder/pellets), liquid filling, tablet compacting on a tablet press, and bottle filling (tablet counting process). Uhlmann VisioTec GmbH, 973/541-6295; firstname.lastname@example.org;
Booth # 1524A
A full line of specialty labels includes a padded label to protect glass vials during processing and shipping. The new Pharma-Cushion label features a layer of foam on the label’s reverse side that securely wraps around glass containers, minimizing the risk of damage while products are being processed or in transport. The Pharma-Cushion label provides pharmaceutical manufacturers with an efficient and eco-friendly packaging and marking solution that avoids complex secondary packaging, which can increase material cost and decrease the number of vials that can be shipped per box. Its thin, flexible material structure affords easy application to glass containers, while the front is used for product identification and other marking purposes. The Pharma-Cushion label is designed to ensure consistent integrity of the container, thus avoiding possible contamination of the drugs inside the vial, and also to protect healthcare personnel, who can be injured by damaged vials. Schreiner MediPharm, a business unit of Schreiner Group LP, Blauvelt, NY; 845/848-9000;
Several industrial PC controlled checkweighers will be on display at Interphex. With the new model, the HC-Medium, the company completes its checkweigher family series: the basic checkweighing with EC-Essential (150ppm) over advanced checkweighing with HC-Medium (250ppm) to HC-Avantgarde (650ppm) for comprehensive applications. All models will be shown next to each other and visitors of the OCS booth can familiarize with the different checkweigher types and take time to find the most suitable checkweigher serving their particular needs. The new HC-MEDIUM is designed for mid-range applications for speeds of up to 250 pieces/minute. It is operated by an industrial PC and is characterized by its 10.4-in. touch display. The HC-M features the same control concept of the high-end checkweigher HC-A making cross training between various controllers a thing of the past. The HC-M is equipped with Wipotec’s EMFR weigh cell unequalled in terms of precision, reliability, and repeatability. OCS Checkweighers Inc., Snellville, GA; 678/344-8300; email@example.com;
An all-inclusive solution for the selection of desiccants, moisture regulators, oxygen absorbers, and volatile adsorbers (sorbents) and their related dispensers is designed to provide pharmaceutical companies with a turnkey solution for promoting the stability of moisture and oxygen sensitive drugs. Calculations through Operations saves pharmaceutical companies six to twelve months development time, creating savings and facilitating a faster time to market. Calculations though Operations unique attributes that separate it from competitors solutions include prediction of drug stability outcome using empirical and pseudo-empirical data (SimulOx and SimulSorb modeling software), providing a more rapid Abbreviated New Drug Application (ANDA) or New Drug Application (NDA) filing. It offers the flexibility to choose Drop-In, Fit-In or Built-In sorbent solutions to fit a specific need. Complete customization of the sorbent and dispenser is possible, and they can be engineered to function as an interdependent system. Smart dispensing technology transmits data, such as lot number, manufacture date, and quantity, from the packet spool to dispenser, easily integrating information into your quality system. As part of the Calculation through Operations program, the company highlights StabilOx specialty oxygen absorbing packets and canisters and StripPax sorbent packets as Drop-In sorbent solutions. StabilOx Packets and Canisters’ work with the product and packaging to resolve product instability issues related to oxygen degradation. StripPax Packets are compact sorbents with a high moisture-adsorbing capacity. Both solutions are available with IntelliSorb sorbent formulations. IntelliSorb formulations’ distinction rests in their ability to react to the packaging headspace environment, providing steady state or multifunctional control of moisture, oxygen, or hydrocarbons. Additionally, Multisorb will provide demonstrations of several system dispensers, including the APA-2000 high-speed StripPax or StabilOx Dispenser with synchronized lug-chain interface (for horizontal flow-wrapping); the APA-2000 high-speed StripPax or StabilOx Dispenser with bottling line interface; and the APA-500 low-speed semi-automated StripPax or StabilOx Dispenser. Multisorb Technologies, Buffalo, NY; 716/824-8900; firstname.lastname@example.org;
A lid has been developed as a means of dosing tablets, capsules, or liquids from plastic bottles in a controlled, more compliant manner. Incorporated into a bottle’s closure, the Dispense Lid features a liner with a small opening that induction seals to high-density polyethylene, polypropylene, and polystyrene bottles. The customized opening feature helps users dispense only the desired number of tablets or capsules. This helps assist with compliance and minimizes the risk of contamination to remaining product. Difficult to copy, the Dispense Lid also aids in anti-counterfeiting measures. It can be customized and easily incorporated into a product’s packaging solution. The company also offers technologies and services include laminating, coating, rotogravure and flexographic printing, metalizing, holography, slitting, in-house graphics preparation, and cylinder engraving. Products include push-through and peelable blister foils; cold-formable foils for absolute barrier to moisture and oxygen; heat-seal coatings for PVC, PVdC, Aclar laminations, PET, PP, and Barex; two-sided registered printing for compliance-style packaging; text- and bar code-printable white-lacquered foils; and child-resistant, senior friendly, and anti-counterfeiting structures. Constantia Flexibles, Blythewood, SC; 803/404-6581;
Booth # 1153
Plastic packaging solutions include a number of vials, desiccant stoppers, and flip-top closures for the pharmaceutical and healthcare industries. Specializing in injection molding techniques, the company offers new products such as the StripTec One for test strips. An integrated drying agent in the base of the vial ensures optimum atmospheric conditions inside the package. One-hand opening ensures user-friendly removal of the test strips and reduced risk of contamination. Its lean, space-saving shape compliments the design of new generation blood glucose monitors. The company will also exhibit its 360º Desiccant Capsules that provide moisture absorption from every angle. The capsules absorb moisture through a cardboard disc on the top as well as through a unique grid structure on the sides of the capsule. This ensures moisture absorption wherever the capsule is located in the container, even when it is on the cardboard side after the container is filled. Current desiccant canisters lose as much as 40% of their moisture absorption capacity when one end of the canister is blocked by the package side wall or its contents. The 360º Capsules allow for easy differentiation from tablets or other solid-dose medications reducing the risk of inadvertent ingestion. 360º Capsules are less likely to break open because the sides withstand greater pressure than competing products. Dust-free silica gel, activated carbon, molecular sieve, or various combinations are available. Its brand new pocket-sized tablet container, TabTec, offers one-hand flip-top opening for dispensing tablets in a hygienic and convenient way. The slim-line profile facilitates the handling and optimally suits today’s “on the go” lifestyle. Effervescent packaging solutions include vials or tubes and stoppers or lids with an integrated desiccant to absorb the moisture. Sanner GmbH, +49 (0) 6221 905 74 20; www.sanner.de .
Booth # 2478
Solutions for preventing foreign tablets and capsules, foreign material, and broken tablets from being packaged at its Interphex are available specifically for pharmaceutical and nutraceutical manufacturers and contract packers. VeriSym optical inspection systems and Impulse/P size graders maximize product quality while reducing the labor costs associated with manual inspection. VeriSym is a compact, high-performance optical inspection system for tablets and softgel capsules that automatically verifies product color, size, and shape and removes foreign tablets and capsules, foreign material, and defects from the product stream. VeriSym inspects up to 1,000,000 tablets or softgels per hour, while VeriSym SL inspects up to 500,000 tablets or softgels per hour. Symetix designed VeriSym/N and VeriSym SL/N for nutraceuticals and VeriSym/P and VeriSym SL/P for OTC and regulated pharmaceuticals. The /P models are FDS 21 CFR part 11 compliant with secure and encrypted logs, secure passcode management, parameter histograms, and guided changeover. The /P models also feature parallel processors that enable operators to monitor images of every object of interest such as unconfirmed objects. Using proprietary color cameras located above and below the product stream, VeriSym views product from top and bottom. Symetix’s image processing technology quickly analyzes the product images, comparing each object to previously defined accept/reject standards. When a defective product or unconfirmed object is identified, the system activates the close-coupled high-speed ejector system to remove it from the acceptable product stream. Impulse/P is a high-capacity size grader that removes broken tablets and fragments when grading tablets and removes twins, clusters, empties, twins, under-filled, and over-filled capsules when grading softgel capsules as well as foreigners of a different size. Featuring removable decks with fixed hole sizes for repeatable grading, Impulse/P can be changed over and sanitized in only five minutes. Impulse/P achieves a throughput of up to 1,000,000 doses per hour, depending on the size of the tablets or capsules. Featuring a large infeed hopper and an electronically-controlled infeed gate, Impulse/P can be easily integrated with upstream and/or downstream equipment or used as a stand-alone size grader handling batches. The customer can batch-feed the bulk-to-bulk Impulse/P today and later integrate the size grader with other continuous processes such as Symetix’s VeriSym. Symetix, 800/941-3701,
A design concept showcases unprecedented technological features simplifying the three primary aspects of tablet press use: changeover, operation, and maintenance. Occupying only 1.6 square meters of floor space, the FE55 can produce up to 500,000 tablets an hour (when utilizing the available 87-station Pmax turret, with segmented technology and FS12 tooling). Even with the available 60-station segmented turret for TSM B tooling the FE55’s output is far greater than that of any other tablet press in its class. Utilizing a single, inverted-cone paddle, the new conical feeder design results in optimized pre- and overall filling, proving itself invaluable for difficult products. Operators or set-up technicians can raise or lower the feeder in relation to the die table surface, in positive-lock steps of 30 microns, by simply sliding a lever back and forth. It is no longer necessary to remove the feeder in order to find the most efficient clearance setting. Completely re-designed compression stations move automatically to their parking position. Moving to reference marks has been eliminated entirely, and by mating the load cells to integrated measuring amplifiers the need for re-calibration has been eliminated. Compression rolls and load cells can be changed in no time, simply by swinging the stations out. High-sensitivity load cells are available for products requiring very low forces and are easily integrated. Fette Compacting America, Excellence United Pavilion, Rockaway, NJ 07866; 973/586-8722; fetteamerica.com/.
A company will exhibit an intermittent motion cartoner along with a series of continuous-motion cartoners. The Romaco Promatic P 91 Intermittent Motion Cartoner features patented carton pick-up and positive opening systems. Fully GMP compliant, the balcony-designed P 91 offers high accessibility, easy cleaning, and reduced risk of contamination. Most of the cartoner’s movements are performed by servo motors and electronic cams, allowing for smooth handling of a wide variety of products. Product transfer is realized by timing belts and pulleys, eliminating the need for chains and mechanical gears. The Promatic P 91’s wide range of tailor-made feeding units load cartons reliably, regardless of differing carton quality. Carton closing options include tuck-in, hot melt, or a combination of both with tamper evidence. The machine offers quick changeover, requires no lubricants in its handling systems, and offers simple integration of quality control devices. A touch screen panel provides complete, efficient diagnostics and troubleshooting functions via text or picture guidance. Individual safety clutches can cease all main movements, serving to avoid mechanical overloads and potential damage to product or machine, while a Venturi vacuum generator greatly diminishes noise during carton pick-up, opening and leaflet feeding. MG America, Fairfield, NJ; 973/808-8185; www.mgamerica.com .