When It Comes to Drug-Device Combos, The Nose Knows
New nasal devices work on innovative packaging systems to get the job done.
Designing and packaging drug-device combos is becoming routine as most MDMs have product portfolios that contain device-based drug delivery. However, as device professionals, when we consider drug delivery, I’m fairly certain we think of different options that probably go in order: oral, injection, respiratory, rectal, trans-dermal, and then maybe the nose.
So why is this? We all know that the nose is an amazing organ and has great capabilities for systemic and local drug application, but within new device developments is seems totally side-lined. Or is it?
There seems to be a renewed interest in developing nasal delivery devices and getting them to market. There are currently two new devices that are in late-stage clinical trials: the OptiNose® from OptiNose US Inc., and the ViaNase® from Kurve Technology.
Each these new devices works on an innovative packaging system based on ensuring that the drug delivered passes the nasal vestibule into the higher nasal cavity. The ViaNase uses an atomizer, and the OptiNose uses the physiology of the nasal cavity to its advantage, combined with self-controlled "breath-powered" delivery.
Both systems are designed to generate drug particles that are much smaller than aqueous sprays. As these devices can be used to deliver drugs both locally and systemically they have concentrated on undertaking clinical trials across a broad spectrum of conditions including rhinitis and polyps (local) and insulin delivery in Alzheimer’s and migraine (systemic). These devices also seek to address user issues that have historically hindered uptake of nasal drug delivery devices such as reliable dosing, dripping, swallowing, and taste of preparations. The devices, through design and packaging, attempt to conquer the battle against the nose in every aspect.
Could these new packaging developments see the start of a new chapter in history for drug-device combinations and nasal drug delivery?
Adele Graham-King, Blogger