Topas COC Helps Deliver Biomaterials
Topas cyclic olefin copolymer (COC) resins are carving out a role in drug delivery. Industry has valued COC’s properties while exploring plastic alternatives for vials and syringes. In another use, Topas has been adopted for delivering biomaterials in operating room skeletal procedures.
Advanced Biomaterials Systems (ABS; Kelsterbach, Germany) uses Topas for the mixing chamber and syringe in its Plexis bone void filling system. Plexis mixes and delivers biomaterials in a single integrated unit for facture stabilization and for filling areas of bone loss. Topas is used in a 4-in.-long × 2-in.-diam mixing chamber and in a 3-in.-long × 0.75-in.-diam syringe body. The syringe body is molded with a 0.0625° draft per side, so the plunger forms a tight seal as it moves.
COC was chosen over other clear resins because it is chemically inert to the biomass, including the powdered bone product and polymethylmethacrylate (PMMA) adhesive, says Barbara Canale, market development, medical applications, Topas Advanced Polymers Inc. (TAP; Florence, KY). TAP is owned by Daicel Chemical Industries Ltd. and Polyplastics Company, Ltd.
“Biocompatibility is required for anything that touches the product. In addition, COC provides absolute glass-clear transparency that allows the surgeon to see that the materials are fully mixed and that material delivery is consistent, and also to gauge the amount of material delivered. The material sets up very quickly and must be placed accurately,” she says.
COC also provides dimensional stability allowing the parts to hold exact dimensions under the pressure of mixing.
“A variety of device manufacturers are currently developing systems using Topas COC, mostly in bone mass treatment, and we expect more new device announcements in the near future,” Canale says.